Azido-PEG4-CH2-Boc

Name: Azido-PEG4-CH2-Boc
Brand: TargetMol
SKU: T14448
Rating: 4.5 (1 reviews)

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产品编号 T14448Cas号 864681-04-9

Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl/ether moieties.

Azido-PEG4-CH2-Boc

还可以

产品编号 T14448Cas号 864681-04-9

规格	价格	库存	数量
2 mg	¥ 152	5日内发货

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产品描述	Azido-PEG4-CH2-Boc is a four-unit cleavable polyethylene glycol (PEG) linker compound employed in the synthesis of antibody-drug conjugates (ADCs)[1] and PROTACs[2]. This linker is characterized by its azide functional group and PEG backbone, facilitating the conjugation of drugs to antibodies in ADC development and enabling the synthesis of PROTACs utilizing PEG and alkyl/ether moieties.
体外活性	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].