Name: QS-21
Brand: TargetMol
SKU: T38838
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

¥ 25,000

5日内发货

生物活性

产品描述	QS-21, an immunostimulatory saponin, is a powerful vaccine adjuvant that stimulates both Th2 humoral and Th1 cell-mediated immune responses by interacting with antigen presenting cells (APCs) and T cells. Additionally, QS-21 activates the NLRP3 inflammasome, leading to the release of cytokines IL-1β and IL-18, which are dependent on caspase-1.
体内活性	Studies in mouse APCs (DCs and macrophages) identifie QS-21 as an activator of the NLRP3 inflammasome, and cause subsequent release of caspase-1 dependent proinflammatory cytokines I1-1β/I1-18 that can promote Th 17 cell maturation or drive INF-γ-mediated Th1 responses, respectively[3].
别名	Stimulon, QS-21

化学信息

分子量	1990.15
分子式	C₉₂H₁₄₈O₄₆
CAS No.	141256-04-4
Smiles	[H][C@@](C[C@H](O)CC(=O)O[C@@]([H])(C[C@H](O)CC(=O)O[C@H]1[C@@H](C)O[C@@H](OC(=O)[C@]23CCC(C)(C)C[C@@]2([H])C2=CC[C@]4([H])[C@@]5(C)CC[C@H](O[C@]6([H])O[C@@H]([C@@H](O)[C@H](O[C@]7([H])OC[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@]6([H])O[C@H](CO)[C@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@]5([H])CC[C@@]4(C)[C@]2(C)C[C@H]3O)[C@H](O[C@]2([H])O[C@@H](C)[C@H](O[C@]3([H])OC[C@@H](O)[C@H](O[C@]4([H])OC[C@](O)(CO)[C@H]4O)[C@H]3O)[C@@H](O)[C@H]2O)[C@H]1O)[C@@H](C)CC)(O[C@@H]1O[C@@H](CO)[C@H](O)[C@H]1O)[C@@H](C)CC