规格

价格

库存

数量

2 mg

¥ 1,950

5日内发货

5 mg

¥ 2,890

5日内发货

25 mg

¥ 10,500

10-14周

50 mg

¥ 13,700

10-14周

100 mg

¥ 18,700

10-14周

1 mL x 10 mM (in DMSO)

¥ 3,180

5日内发货

生物活性

产品描述	PF-00446687 is a selective agonist of melanocortin-4 receptor (MC4R) (EC50 of 12 ± 1 nM).
靶点活性	MC4R:12 ± 1 nM (EC50)
体外活性	PF-00446687 has a relatively weak activity at the MC1, MC3, and MC5 receptors(EC50s of 1.02±0.30 μM, 1.16±0.35 μM, and 1.98±0.20 μM, respectively).
体内活性	Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II (MTII), and the highly selective, small molecule MC4R agonist, Pf-446687, enhances partner preference formation in the prairie vole, but not in the non-monogamous meadow vole[2].

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 62.5 mg/mL (132.81 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.31 mM), Sonication is recommeded.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO