MF498

Name: MF498
Brand: TargetMol
SKU: T16069
Rating: 4.5 (1 reviews)

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产品编号 T16069Cas号 915191-42-3

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).

MF498

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产品编号 T16069Cas号 915191-42-3

MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).

规格	价格	库存
1 mg	待估	35日内发货
5 mg	待估	35日内发货
10 mg	待估	35日内发货
25 mg	待估	35日内发货

大包装 & 定制

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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产品介绍

生物活性

产品描述	MF498 is a novel and selective E prostanoid receptor 4 (EP4 receptor) antagonist, displayed a strong binding affinity for the EP4 receptor (Ki: 0.7 nM).
靶点活性	EP4:0.7 nM (Ki)
体外活性	MF498 inhibits PGE2-stimulated cAMP accumulation in a dose-dependent manner (IC50: 1.7 and 17 nM in the absence and presence of 10% serum, respectively). MF498 also displays a relatively good selectivity over other prostanoid receptors, does not compromise the mucosal integrity in the gastrointestinal tract.
体内活性	MF498 on inflammation in adjuvant-caused arthritis (AIA), a rat model for rheumatoid arthritis (RA), and joint pain in a guinea pig model of iodoacetate-induced osteoarthritis (OA). MF498 relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.

化学信息

分子量	603.69
分子式	C₃₂H₃₃N₃O₇S
CAS No.	915191-42-3
密度	1.324 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 31 mg/mL (51.35 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6565 mL	8.2824 mL	16.5648 mL	82.8240 mL
5 mM	0.3313 mL	1.6565 mL	3.3130 mL	16.5648 mL
10 mM	0.1656 mL	0.8282 mL	1.6565 mL	8.2824 mL
20 mM	0.0828 mL	0.4141 mL	0.8282 mL	4.1412 mL
50 mM	0.0331 mL	0.1656 mL	0.3313 mL	1.6565 mL