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Modecainide is metabolite of Encainide, is an antiarrhythmic agent.
Modecainide is metabolite of Encainide, is an antiarrhythmic agent.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 2,120 | 5日内发货 |
产品描述 | Modecainide is metabolite of Encainide, is an antiarrhythmic agent. |
体内活性 | O-demethylated Encainide (MJ 9444) and 3-O-methoxy Encainide (MJ 14030), on cardiac conduction is studied by recording His bundle potentials in isolated perfused rabbit hearts and Purkinje and muscle conduction in vivo in dog hearts after destruction of the atrioventricular node. Both metabolites are 4 to 15 times more potent than Encainide in slowing conduction through the atria, the AV-node and the His-Purkinje system of the rabbit heart. In the dog, Encainide (0.8-3.2 mg/kg i.v.) slows conduction of extrasystoles in both Purkinje and muscle at all coupling intervals, increases the effective refractory period and the functional refractory period of the Purkinje pathway[1]. |
别名 | MJ 14030, BMY 40327 |
分子量 | 368.47 |
分子式 | C22H28N2O3 |
CAS No. | 81329-71-7 |
密度 | 1.162g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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