Anti-C1s Antibody (6O90)

Name: Anti-C1s Antibody (6O90)
Brand: TargetMol
SKU: TMAY-00484
Rating: 4.5 (1 reviews)

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产品编号 TMAY-00484

Anti-C1s Antibody (6O90) 是一种 Rabbit 抗体，靶向 C1s。Anti-C1s Antibody (6O90) 可用于 ELISA。

Anti-C1s Antibody (6O90)

还可以

产品编号 TMAY-00484

Anti-C1s Antibody (6O90) 是一种 Rabbit 抗体，靶向 C1s。Anti-C1s Antibody (6O90) 可用于 ELISA。

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产品描述	Anti-C1s Antibody (6O90) is a Rabbit antibody targeting C1s. Anti-C1s Antibody (6O90) can be used in ELISA.
Ig Type	Monoclonal Rabbit IgG
克隆号	6O90
交叉反应	Human
应用	ELISA
推荐剂量	ELISA: 1:5000-1:10000
抗体种类	Monoclonal
宿主来源	Rabbit
构建方式	This antibody was obtained from a rabbit immunized with purified, recombinant Human Complement C1s (rh Complement C1s; TMPY-06585; NP_001725.1; Met 1-Asp 688).
纯化方式	Protein A
性状	Liquid
缓冲液	0.2 μm filtered solution in PBS
研究背景	Complement is an integral component of the adaptive and innate immune systems and represents one of the major effector systems for the immune responses. The classical complement pathway is triggered by C1, a complex composed of the binding protein C1q and two proenzymes, C1r and C1s. Upon binding of IgG to the head of C1q, C1r undergoes autoactivation and in turn cleaves and activates C1s. C1r and C1s, the proteases responsible for activation and proteolytic activity of the C1 complex of complement, share similar overall structural organizations featuring five nonenzymic protein modules (two CUB modules surrounding a single EGF module, and a pair of CCP modules) followed by a serine protease domain. Besides highly specific proteolytic activities, both proteases exhibit interaction properties associated with their N-terminal regions. In contrast, C1r and C1s widely differ from each other by their glycosylation patterns: both proteins contain Asn-linked carbohydrates, but four glycosylation sites are present on C1r, and only two on C1s. As a highly specific serine protease, C1s executes the catalytic function of the C1 complex: the cleavage of C4 and C2, and thus instigates a sequence of activation steps of other components of the complement system, culminating in the formation of the membrane attack complex which induces cell lysis. Like other complement serine proteases C1s has restricted substrate specificity and it is engaged into specific interactions with other subcomponents of the complement system. The only other protein known to interact with C1s physiologically is SerpinC1, an inhibitor of serine protease, which inhibits C1s activity and thus plays a regulatory role in controlling the function of C1s enzyme.

偶联与修饰

偶联	Unconjugated

抗原信息

免疫原	Recombinant Human Complement C1s protein (TMPY-06585)
抗原种属	Human

存储&运输

储存方式	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式	Shipping with blue ice.