规格

价格

库存

数量

1 mg

¥ 9,385

待询

5 mg

¥ 21,285

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10 mg

¥ 39,985

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50 mg

待询

100 mg

待询

1 mL x 10 mM (in DMSO)

¥ 34,275

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生物活性

产品描述	D8-MMAD is a deuterated form of MMAD (T4677), which is a microtubule destroyer.
体外活性	MMAD (monomethyl Dolastatin 10) is coupled through a stable oxime ligation process to produce several nearly uniform antibody-drug conjugates (ADC) with a pharmacodynamic ratio of approximately 2.0. The resulting conjugate showed good pharmacokinetic properties and had strong in vitro cytotoxic activity against HER2 + cancer cells. Compared with ADCs prepared by cysteine alkylation after reduction of natural interchain disulfide bonds, site-based unnatural amino acid-based ADCs have higher cytotoxicity in vitro.
体内活性	The resulting antibody-drug conjugate (ADC) showed complete tumor regression in rodents. Their toxicological characteristics in rats have also been improved.
别名	Monomethylauristatin D D8, Monomethyl Dolastatin 10 D8, Demethyldolastatin 10 D8

化学信息

分子量	779.11
分子式	C₄₁H₅₈D₈N₆O₆S
Smiles	O=C(N[C@H](C1=NC=CS1)CC2=CC=CC=C2)[C@H](C)[C@@H](OC)[C@H]3N(C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C([C@@](C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])([2H])NC([C@H](C(C)C)NC)=O)=O)C)=O)CCC3
密度	no data available

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 100 mg/mL (128.35 mM), Sonication is recommended.

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

D8-MMAD