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Anti-AKT1 Antibody (2R814)
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产品编号 TMAC-00123
别名 v-akt murine thymoma viral oncogene homolog 1, RAC-α, RAC-ALPHA, RAC, PRKBA, PKB-α, PKB-ALPHA, PKB, CWS6, AKT
Anti-AKT1 Antibody (2R814) 是一种 Rabbit 抗体，靶向 AKT1。Anti-AKT1 Antibody (2R814) 可用于 WB,ICC/IF,IHC,IP,FCM。
Anti-AKT1 Antibody (2R814)
Anti-AKT1 Antibody (2R814)
还可以产品编号 TMAC-00123 别名 v-akt murine thymoma viral oncogene homolog 1, RAC-α, RAC-ALPHA, RAC, PRKBA, PKB-α, PKB-ALPHA, PKB, CWS6, AKT
Anti-AKT1 Antibody (2R814) 是一种 Rabbit 抗体，靶向 AKT1。Anti-AKT1 Antibody (2R814) 可用于 WB,ICC/IF,IHC,IP,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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产品介绍
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偶联与修饰
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化学信息
| 产品描述 | Anti-AKT1 Antibody (2R814) is a Rabbit antibody targeting AKT1. Anti-AKT1 Antibody (2R814) can be used in WB,ICC/IF,IHC,IP,FCM. |
| 别名 | v-akt murine thymoma viral oncogene homolog 1, RAC-α, RAC-ALPHA, RAC, PRKBA, PKB-α, PKB-ALPHA, PKB, CWS6, AKT |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse,Rat |
| 验证活性 | 1. Western blot analysis of AKT1 on MCF-7 cell lysates using anti-AKT1 antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-AKT1 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-AKT1 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse prostate tissue using anti-AKT1 antibody. Counter stained with hematoxylin. 5. Immunohistochemical analysis of paraffin-embedded mouse kidney tissue using anti-AKT1 antibody. Counter stained with hematoxylin. 6. Flow cytometric analysis of Hela cells with AKT1 antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody. |
| 应用 | |
| 推荐剂量 | WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | The serine/threonine kinase Akt family contains several members, including Akt1 (also designated PKB or RacPK), Akt2 (also designated PKBβor RacPK-β) and Akt 3 (also designated PKB? or thyoma viral proto-oncogene 3), which exhibit sequence homology with the protein kinase A and C families and are encoded by the c-Akt proto-oncogene. All members of the Akt family have a pleckstrin homology domain. Akt1 and Akt2 are activated by PDGF stimulation. This activation is dependent on PDGFR-β tyrosine residues 740 and 751, which bind the subunit of the phosphatidylinositol 3-kinase (PI 3-kinase) complex. Activation of Akt1 by insulin or insulin-growth factor-1(IGF-1) results in phosphorylation of both Thr 308 and Ser 473. Phosphorylation of both residues is important to generate a high level of Akt1 activity, and the phosphorylation of Thr 308 is not dependent on phosphorylation of Ser 473 in vivo. Thus, Akt proteins become phosphorylated and activated in insulin/IGF-1-stimulated cells by an upstream kinase(s). The activation of Akt1 and Akt2 is inhibited by the PI kinase inhibitor wortmannin, suggesting that the protein signals downstream of the PI kinases. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 56 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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