Anti-ITK Antibody (2V780)

Name: Anti-ITK Antibody (2V780)
Brand: TargetMol
SKU: TMAH-00652
Rating: 4.5 (1 reviews)

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产品编号 TMAH-00652

别名 PSCTK2, LYK, LPFS1, IL2-inducible T-cell kinase, EMT

Anti-ITK Antibody (2V780) 是一种抗体，靶向 ITK。Anti-ITK Antibody (2V780) 可用于 ELISA, IHC。

Anti-ITK Antibody (2V780)

还可以

产品编号 TMAH-00652 别名 PSCTK2, LYK, LPFS1, IL2-inducible T-cell kinase, EMT

Anti-ITK Antibody (2V780) 是一种抗体，靶向 ITK。Anti-ITK Antibody (2V780) 可用于 ELISA, IHC。

规格	价格	库存	数量
50 μL	¥ 1,300	5日内发货
100 μL	¥ 2,195	5日内发货

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产品描述	Anti-ITK Antibody (2V780) is an antibody targeting ITK. Anti-ITK Antibody (2V780) can be used in ELISA, IHC.
别名	PSCTK2, LYK, LPFS1, IL2-inducible T-cell kinase, EMT
Ig Type	Rabbit IgG
克隆号	2V780
交叉反应	Human
验证活性	IHC image of TMAH-00652 diluted at 1:100 and staining in paraffin-embedded human lymph node tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
应用	ELISA, IHC
推荐剂量	IHC:1:50-1:200.
抗体种类	Monoclonal
亚细胞定位	Cytoplasm. Nucleus. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.
构建方式	Recombinant Antibody
纯化方式	Affinity-chromatography
性状	Liquid
缓冲液	Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景	Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells. Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3.