AGN 210676 is a selective agonist of prostaglandin EP2(EC50 : 5 nM).

EP2 receptor:5 nM （EC50）, EP3A receptor (human):153 nM （EC50）, DP receptor (human):7749 nM （EC50）

AGN 210676 is useful for the treatment of glaucoma, ocular hypertension, inflammatory bowel disease, and the other diseases or conditions disclosed herein[1]. AGN 210676 (Compound 23) also is a less potent agonist for recombinant human prostaglandin receptors hEP3A and hDP with EC50s of 153 nM and 7749 nM, respectively.