规格

价格

库存

数量

10 mg

¥ 7,170

35日内发货

生物活性

产品描述

NF546 is a selective agonist of non-nucleotide P2Y11(pEC50 of 6.27).

体外活性

The selective non-nucleotide P2Y(11) agonist NF546 was identified.?NF546 had a pEC(50) of 6.27 and is relatively selective for P2Y(11) over P2Y(1), P2Y(2), P2Y(4), P2Y(6), P2Y(12), P2X(1), P2X(2), and P2X(2)-X(3).?The pA(2) of NF340 was 8.02 against ATPgammaS and 8.04 against NF546 (calcium assays).?NF546 was further tested for P2Y(11)-mediated effects in monocyte-derived dendritic cells.?Similarly to ATPgammaS, NF546 led to thrombospondin-1 secretion and inhibition of lipopolysaccharide-stimulated interleukin-12 release, whereas NF340 inhibited these effects.?Further, for the first time, it was shown that ATPgammaS or NF546 stimulation promotes interleukin 8 (IL-8) release from dendritic cells, which could be inhibited by NF340.

化学信息

分子量	1180.74
分子式	C₄₇H₄₄N₆Na₄O₁₇P₄
CAS No.	1006028-37-0
Smiles	[Na].[Na].[Na].[Na].Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(CP(O)(O)=O)cc2CP(O)(O)=O)c1)C(=O)Nc1ccc(CP(O)(O)=O)cc1CP(O)(O)=OjcExt:v:0:0,1:0,2:0,3:0
密度	no data available