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Anti-MRP2/ABCC2 Polyclonal Antibody
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还可以产品编号 TMAB-01169
别名 multidrug resistance-associated protein2, Multidrug resistance associated protein 2, MRP2, MRP 2, KIAA1010, DJS, cMRP, CMOAT1, CMOAT, Canalicular multispecific organic anion transporter 1, Canalicular multidrug resistance protein, ATP-binding cassette sub-family C member 2, ATP binding cassette subfamily C member 2, ATP binding cassette sub family C(CFTR/MRP) member 2, ABCC2, ABC30
Anti-MRP2/ABCC2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MRP2/ABCC2。Anti-MRP2/ABCC2 Polyclonal Antibody 可用于 FCM,IF,IHC-Fr,IHC-P。
Anti-MRP2/ABCC2 Polyclonal Antibody
Anti-MRP2/ABCC2 Polyclonal Antibody
一键复制产品信息 还可以产品编号 TMAB-01169 别名 multidrug resistance-associated protein2, Multidrug resistance associated protein 2, MRP2, MRP 2, KIAA1010, DJS, cMRP, CMOAT1, CMOAT, Canalicular multispecific organic anion transporter 1, Canalicular multidrug resistance protein, ATP-binding cassette sub-family C member 2, ATP binding cassette subfamily C member 2, ATP binding cassette sub family C(CFTR/MRP) member 2, ABCC2, ABC30
Anti-MRP2/ABCC2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MRP2/ABCC2。Anti-MRP2/ABCC2 Polyclonal Antibody 可用于 FCM,IF,IHC-Fr,IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,160 | 5日内发货 | |
| 100 μL | ¥ 1,960 | 5日内发货 | |
| 200 μL | ¥ 2,780 | 5日内发货 |
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| 产品描述 | Anti-MRP2/ABCC2 Polyclonal Antibody is a Rabbit antibody targeting MRP2/ABCC2. Anti-MRP2/ABCC2 Polyclonal Antibody can be used in FCM,IF,IHC-Fr,IHC-P. |
| 别名 | multidrug resistance-associated protein2, Multidrug resistance associated protein 2, MRP2, MRP 2, KIAA1010, DJS, cMRP, CMOAT1, CMOAT, Canalicular multispecific organic anion transporter 1, Canalicular multidrug resistance protein, ATP-binding cassette sub-family C member 2, ATP binding cassette subfamily C member 2, ATP binding cassette sub family C(CFTR/MRP) member 2, ABCC2, ABC30 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Paraformaldehyde-fixed, paraffin embedded Human Liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Antibody incubation with MRP2/ABCC2 Polyclonal Antibody, Unconjugated (TMAB-01169) at 1:200 overnight at 4°C, followed by conjugation to the SP Kit (Rabbit) and DAB staining. 2. The A549 (H) cells were fixed with 4% PFA (10 min at room temperature). Primary Antibody (green): Rabbit Anti-MRP2/ABCC2 antibody (TMAB-01169): 1 μg/10^6 cells; Secondary Antibody (white blue): Goat anti-Rabbit IgG-FITC: 1 μg/test. Isotype Control (orange): Rabbit IgG. Blank control (black): PBS.   |
| 应用 | FCMIFIHC-FrIHC-P |
| 推荐剂量 | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/Test |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. Belongs to the ABC transporter family. |
| 免疫原 | KLH conjugated synthetic peptide: human MRP2 |
| 抗原种属 | Human |
| 基因名称 | ABCC2 |
| 基因ID | |
| 蛋白名称 | Canalicular multispecific organic anion transporter 1 |
| Uniprot ID | |
| 研究领域 | MRP-related proteins,Channels |
| 功能 | Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. |
| 分子量 | Theoretical: 174 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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