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Anti-Patched Polyclonal Antibody
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产品编号 TMAB-01337
别名 Ptch2, PTCH11, PTCH1, PTCH protein-10, PTCH protein+4', PTCH protein+12b, PTCH protein, PTCH, PTC1, PTC, PT1, Protein patched homolog 1, Patched/PTCH, Patched(Drosophila) homolog, Patched protein homolog 1, Patched homolog(Drosophila), Patched homolog 1(Drosophila), Patched homolog 1, Patched 1, Patched, OTTHUMP00000021710, OTTHUMP00000021709, NBCCS, mes, HPE7, Holoprosencephaly 7, FLJ42602, FLJ26746, BCNS, A230106A15Rik
Anti-Patched Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Patched。Anti-Patched Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA。
Anti-Patched Polyclonal Antibody
Anti-Patched Polyclonal Antibody
还可以产品编号 TMAB-01337 别名 Ptch2, PTCH11, PTCH1, PTCH protein-10, PTCH protein+4', PTCH protein+12b, PTCH protein, PTCH, PTC1, PTC, PT1, Protein patched homolog 1, Patched/PTCH, Patched(Drosophila) homolog, Patched protein homolog 1, Patched homolog(Drosophila), Patched homolog 1(Drosophila), Patched homolog 1, Patched 1, Patched, OTTHUMP00000021710, OTTHUMP00000021709, NBCCS, mes, HPE7, Holoprosencephaly 7, FLJ42602, FLJ26746, BCNS, A230106A15Rik
Anti-Patched Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Patched。Anti-Patched Polyclonal Antibody 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,175 | 5日内发货 | |
| 100 μL | ¥ 1,965 | 5日内发货 | |
| 200 μL | ¥ 2,785 | 5日内发货 |
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产品介绍
生物活性
抗原信息
化学信息
| 产品描述 | Anti-Patched Polyclonal Antibody is a Rabbit antibody targeting Patched. Anti-Patched Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA. |
| 别名 | Ptch2, PTCH11, PTCH1, PTCH protein-10, PTCH protein+4', PTCH protein+12b, PTCH protein, PTCH, PTC1, PTC, PT1, Protein patched homolog 1, Patched/PTCH, Patched(Drosophila) homolog, Patched protein homolog 1, Patched homolog(Drosophila), Patched homolog 1(Drosophila), Patched homolog 1, Patched 1, Patched, OTTHUMP00000021710, OTTHUMP00000021709, NBCCS, mes, HPE7, Holoprosencephaly 7, FLJ42602, FLJ26746, BCNS, A230106A15Rik |
| Ig Type | IgG |
| 交叉反应 | Human,Mouse (predicted:Rat,Chicken,Cow,Horse,Rabbit) |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000 |
| 抗体种类 | Polyclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Membrane. |
| 组织特异性 | In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin. |
| 构建方式 | Polyclonal Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | PTCH (Patched protein homolog 1) is a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). PTCH associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal.PTCH has a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. PTCH is expressed in the adult brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. It is also expressed in tumor cells but not in normal skin. During development PTCH is found in all major target tissues of sonic hedgehog, such as the ventral neural tube, somites, and tissues surrounding the zone of polarizing activity of the limb bud. Defects in PTCH are probably the cause of basal cell nevus syndrome also known as Gorlin syndrome or Gorlin-Goltz syndrome. |
| 免疫原 | KLH conjugated synthetic peptide: human Patched/PTCH |
| 抗原种属 | Human |
| 基因名称 | PTCH1 |
| 基因ID | |
| 蛋白名称 | Protein patched homolog 1 |
| Uniprot ID | |
| 研究领域 | PTC & Wnt pathway,Cell Cycle Inhibitors,Neurogenesis,Surface Molecules |
| 功能 | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. |
| 分子量 | Theoretical: 161 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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