L-Praziquanamine, the enantiomer of praziquanamine, exhibits parasiticidal activity against Schistosoma spp., including Schistosoma japonicum. This compound disrupts calcium homeostasis (Ca(2+)), leading to muscle contraction, tegumental damage, and ultimately the death of the parasite. Therefore, L-Praziquanamine holds potential as a therapeutic agent for schistosomiasis treatment.