Name: CA-170
Brand: TargetMol
SKU: T12378L
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

25 mg

¥ 18,900

8-10周

50 mg

¥ 24,800

8-10周

100 mg

¥ 28,500

8-10周

生物活性

产品描述	CA-170 is an orally bioavailable dual inhibitor of VISTA and PD-L1 that selectively restores T-cell proliferation and effector function suppressed by immune checkpoint signaling, while demonstrating minimal off-target activity across a broad receptor and enzyme panel, making CA-170 a valuable compound for immuno-oncology research and immune checkpoint modulation studies.
体外活性	PD-1 is a co-receptor that is expressed predominantly by T cells. The binding of PD-1 to its ligands, PD-L1 or PD-L2, is important for the physiological regulation of the immune system[1].
体内活性	在利用同系小鼠肿瘤模型（如结直肠癌和黑色素瘤）进行的临床前研究中，口服给予 CA-170 可抑制肿瘤生长 [1]。
别名	PD-1-IN-1, CA170, CA 170

化学信息

分子量	360.32
分子式	C₁₂H₂₀N₆O₇
CAS No.	1673534-76-3
Smiles	[C@H](NC(N[C@@H]([C@@H](C)O)C(O)=O)=O)(CC(N)=O)C1=NC([C@H](CO)N)=NO1
密度	1.536 g/cm3 (Predicted)

储存&溶解度

存储

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 24 mg/mL (66.61 mM), Sonication is recommended.

溶液配制表

DMSO

CA-170