Name: Abatacept
Brand: TargetMol
SKU: T10218
Price: 8150 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

5 mg

¥ 8,150

现货

生物活性

产品描述	Abatacept (CTLA4lg) is a soluble fusion protein consisting of the extracellular domain of human CTLA4 and a fragment of the Fc portion of human IgG1 (hinge and CH2 and 3 domains). It is a selective T-cell co-stimulation modulator and a protein drug for autoimmune diseases.
体内活性	Abatacept reduces paw edema, and the SC Multiple-dose group shows significantly greater (tobs = 2.50) paw edema reduction compared with the IV dose group. Abatacept exhibits linear PK across the studied doses. The NCA clearance (CL) is 20.8 mL/day/kg, volume (Vss) is 146 mL/kg, and bioavailability (F) of the SC dose dosing is 57.7% [2]. Abatacept (oral; 10 mg/kg; every 2 days) reduces the proportion of activated T cells (CD44highCD62L–) and inhibits the up-regulation of ICOS and CD71 in homozygous DO11.10 RAG-2–/–BALB/c (H-2d/d) mice [3].
动物实验	Animal Model: Male Lewis rats (6-9 weeks old) with weights of 150-175 g. Dosage: 10 mg/kg (i.v.), 20 mg/kg (s.c. single-dose), 20 mg/kg (SC Multiple-dose) on day 21 with 10 mg/kg SC doses on days 23, 25, 27, and 29. Administration: i.v. or s.c. [2]
别名	CTLA4lg
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
内毒素	<1.0 EU/mg

偶联与修饰

偶联	Unconjugated

化学信息

储存&溶解度

存储	store at low temperature \| -20°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Abatacept