Isoindigotin

Name: Isoindigotin
Brand: TargetMol
SKU: T1840
Price: 117 CNY
Availability: InStock
Rating: 5 (10 reviews)

一键复制产品信息

很棒

纯度: 98.967%

货号 T1840Cas号 476-34-6

Isoindigotin 用于治疗 Y.

Isoindigotin

一键复制产品信息

很棒

纯度: 98.967%

货号 T1840Cas号 476-34-6

Isoindigotin 用于治疗 Y.

规格	价格	库存	数量
25 mg	¥ 147	现货
1 mL x 10 mM (in DMSO)	¥ 117	现货

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产品介绍

Isoindigotin AI Summary

Isoindigotin exhibits a broad spectrum of bioactivities, including significant antiproliferative effects against various human tumor cell lines such as HL60, K562, and KB cells, with inhibitory percentages of 53.0%, 64.0%, and 92.0% at 10 µM after 72 hours, respectively. It has an IC50 value of 1600.0 nM for KB cells. In addition to its anticancer properties, it induces NQO1 and CYP1A1 activities in mouse Hepa-1c1c7 cells, showing a moderate induction at 0.1 µM after 48 hours by MTT and EROD assays. It also exhibits cytotoxicity against Hepa-1c1c7 cells over 48 hours. Isoindigotin acts as an inhibitor of human transglutaminase 2 with an IC50 value of 8000.0 nM and a Ki value of 41000.0 nM. Furthermore, it demonstrates growth inhibition activity across a variety of human tumor cell lines, including breast, renal, melanoma, lung, ovarian, prostate, colon, leukemia, and central nervous system cells, with GI50 values ranging from low to high nanomolar concentrations. Additionally, it has antimicrobial activity against Mycobacterium tuberculosis H37Rv in African green monkey Vero cells, with a MIC of 27000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Isoindigotin is used in the therapy of Y.

化学信息

分子量	262.26
分子式	C₁₆H₁₀N₂O₂
CAS No.	476-34-6
Smiles	O=C1Nc2ccccc2C1=C1C(=O)Nc2ccccc12
密度	1.417g/cm3
颜色	Red
物理性状	solid

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 9 mg/mL (34.32 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8130 mL	19.0650 mL	38.1301 mL	190.6505 mL
5 mM	0.7626 mL	3.8130 mL	7.6260 mL	38.1301 mL
10 mM	0.3813 mL	1.9065 mL	3.8130 mL	19.0650 mL
20 mM	0.1907 mL	0.9533 mL	1.9065 mL	9.5325 mL