Name: GKA50
Brand: TargetMol
SKU: T11401
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

50 mg

¥ 5,220

6-8周

100 mg

¥ 8,090

6-8周

生物活性

产品描述	GKA50 stimulates insulin release from mouse islets of Langerhans and MIN6 cells. GKA50 shows significant glucose lowering in high fat fed female rats. GKA50 is a potent glucokinase activator (EC50=33 nM at 5 mM glucose).
体外活性	GKA50 activates human glucokinase enzymatic activity with an EC50 of 0.022 μM.?GKA50 stimulates insulin secretion in the pancreatic insulinoma cell line, INS-1, with an EC50 of 0.065 μM.?GKA50 reduces chronic-high-glucose-induced apoptosis via modulation of glucokinase and apoptotic protein BAD.GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC50values ranging from 1 to 2 μM. GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells.
体内活性	GKA50?gives significant glucose lowering in an oral glucose tolerance test.