Name: JNJ-5207787
Brand: TargetMol
SKU: T15620
Price: 1080 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 1,080

现货

5 mg

¥ 3,520

现货

10 mg

¥ 4,920

现货

生物活性

产品描述	JNJ-5207787 is a blood–brain barrier penetrant neuropeptide Y Y2 receptor antagonist that demonstrates greater than 100-fold selectivity over Y1, Y4, and Y5 receptor subtypes, JNJ-5207787 potently suppresses peptide YY binding at both human and rat Y2 receptors, supporting the use of JNJ-5207787 in central nervous system research focused on neuropeptide signaling.
靶点活性	Y2 receptor (human):7.0 (pic50), Y2 receptor (rat):7.1 (pic50)
体外活性	JNJ-5207787 (10 μM; 15 min) suppresses [125I]PYY labeling in the lateral septum, cerebellum, ventral tegmental area, substantia nigra, hippocampus, septum, amygdala, and hypothalamus. JNJ-5207787 (0.01, 0.1, 1, 10 μM) has antagonistic properties and suppresses the PYY-stimulated [35S]GTPγS binding to basal level with a p IC50 corr of 7.20 [1].
体内活性	JNJ-5207787 (i.p.; 30 mg/kg) penetrates the brain (Cmax=1351 ng/ml at 30 min) and occupies Y2 receptor binding sites[1].
别名	JNJ5207787, JNJ 5207787

化学信息

分子量	510.67
分子式	C₃₂H₃₈N₄O₂
CAS No.	683746-68-1
Smiles	N(C(/C=C/C1=CC(C#N)=CC=C1)=O)(C=2C=C3C(=CC2)CCN3C(C)=O)C4CCN(CCC5CCCC5)CC4
密度	1.22 g/cm3
颜色	Yellow
物理性状	Solid