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METTL11A Protein, Human, Recombinant (GST)

产品编号 TMPY-01284

别名: C9orf32, AD-003, METTL11A, HOMT1A, N-terminal Xaa-Pro-Lys N-methyltransferase 1, NTM1A, NRMT

METTL11A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 52.2 kDa and the accession number is A0A024R8E4.

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METTL11A Protein, Human, Recombinant (GST)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	METTL11A Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 52.2 kDa and the accession number is A0A024R8E4.

种属	Human
表达系统	E. coli
标签	N-GST
蛋白编号	A0A024R8E4
别名	C9orf32, AD-003, METTL11A, HOMT1A, N-terminal Xaa-Pro-Lys N-methyltransferase 1, NTM1A, NRMT
蛋白构建	The Human METTL11A (NP_054783.2) (Thr 2-Arg 223) was fused with the GST tag at the N-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE
分子量	52.2 kDa (predicted)

内毒素	Please contact us for more information.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM tris 150 mM NaCl, 0.5 mM GSH 10% glycerol, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Methylation often occurs on nucleic bases in DNA or amino acids in protein structures. Methyltransferase uses a reactive methyl group bound to sulfur in S-adenosyl methionine (SAM) as the methyl donor. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. This methylation occurs on cytosine residues. DNA methylation may be necessary for normal growth from embryonic stages in mammals. Methylation can serve to protect DNA from enzymatic cleavage since restriction enzymes are unable to bind and recognize externally modified sequences. This is especially useful in bacterial restriction-modification systems which use restriction enzymes to cleave foreign DNA while keeping their DNA protected by methylation. Methylation of amino acids in the formation of proteins leads to more diversity of possible amino acids and therefore more diversity of function. The methylation reaction occurs on nitrogen atoms either on the N terminus or side-chain position of the protein and is usually irreversible.

参考文献

1. Hu R.-M., et al.,(2000), Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548. 2. Ota T., et al., (2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45. 3. Humphray S.J., et al.,(2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.

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Keywords

METTL11A Protein, Human, Recombinant (GST) C9orf32 AD 003 AD-003 AD003 METTL11A HOMT1A N-terminal Xaa-Pro-Lys N-methyltransferase 1 NTM1A NRMT recombinant recombinant-proteins proteins protein

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