Name: PROTAC FKBP Degrader-3
Brand: TargetMol
SKU: T18610
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

1 mg

¥ 4,890

10-14周

5 mg

¥ 9,870

10-14周

10 mg

¥ 13,500

10-14周

25 mg

¥ 19,700

10-14周

50 mg

¥ 27,200

10-14周

100 mg

¥ 36,700

10-14周

生物活性

产品描述	PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an VHL binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader[1].
体外活性	PROTAC treatment time courses demonstrated a notable increase in polyubiquitination of EGFP-FKBP in response to treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) for VHL within the first hour. Upon recruiting endogenous VHL via PROTAC FKBP Degrader-3 (compound 10), only one EGFP background lysine (Lys158) is found to be ubiquitylated[1].

化学信息

分子量	1295.54
分子式	C₆₈H₉₀N₆O₁₇S
CAS No.	2079056-43-0
Smiles	CC[C@H](C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCc1ccc(OC)c(OC)c1)c1cccc(OCC(=O)NCCOCCOCCOCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)c1)c1cc(OC)c(OC)c(OC)c1
密度	1.233 g/cm3 (Predicted)