Name: LAIR1 Protein, Human, Recombinant (His & Avi)
Brand: TargetMol
SKU: TMPK-00177
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 μg

¥ 343

6-8日内发货

10 μg

¥ 549

6-8日内发货

20 μg

¥ 898

5日内发货

50 μg

¥ 1,760

5日内发货

100 μg

¥ 2,960

5日内发货

200 μg

¥ 5,350

5日内发货

500 μg

¥ 11,800

5日内发货

生物活性

产品描述	LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
生物活性	1. Immobilized Human LAIR1, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-LAIR1 Antibody, hFc Tag with the EC50 of 15.3ng/ml determined by ELISA. 2. Human LAIR1, His Tag captured on CM5 Chip via Anti-His Antibody can bind Native Human Collagen I protein with an affinity constant of 0.082 nM as determined in SPR assay.
研究背景	LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
种属	Human
表达系统	HEK293 Cells
标签	C-His-Avi
蛋白编号	Q6GTX8-1
蛋白构建	Gln22-His163
蛋白纯度	> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
蛋白性状	Lyophilized powder
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS (pH 7.4). Typically, 8% trehalose is incorporated as a protective agent before lyophilization.
复溶方法	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
别名	LAIR-1, LAIR1, HLAIR1, CD305
内毒素	< 1 EU/μg by the LAL method.

化学信息

分子量	18.2 kDa (predicted). Due to glycosylation, the protein migrates to 30-36 kDa based on Tris-Bis PAGE result.

储存&溶解度

运输方式	In general, Lyophilized powders are shipping with blue ice.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

LAIR1 Protein, Human, Recombinant (His & Avi)

LAIR1 Protein, Human, Recombinant (His & Avi)

产品介绍

计算器

剂量转换

引用文献

技术支持

关键词