Name: Brevetoxin-3
Brand: TargetMol
SKU: T10609
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

100 μg

¥ 8,900

35日内发货

生物活性

产品描述	Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.
靶点活性	Na+-ATPase:
体外活性	Brevetoxin-3 (30-500 nM) produces a shift in activation to more negative membrane potentials whereby single-channel activity is observed under steady-state conditions (maintained depolarization at -50 mV) [1].
体内活性	Brevetoxin-3 (intratracheal instillation; 2.8 μg/kg; gestational days 15-18) radioactivity is detected in placentas and fetuses within 0.5 hours. Concentrations of brevetoxin equivalents in fetuses are approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh [3].
别名	PbTx-3

化学信息

分子量	897.112
分子式	C₅₀H₇₂O₁₄
CAS No.	85079-48-7
Smiles	[H][C@]12C[C@@]3([H])O[C@H](CC(=C)CO)C[C@H](O)[C@]3(C)O[C@]1([H])C[C@]1([H])O[C@]3([H])C[C@]4(C)O[C@]5(C)CC[C@]6([H])O[C@]7([H])C[C@]8(C)O[C@]9([H])C(C)=CC(=O)O[C@@]9([H])C[C@@]8([H])O[C@@]7([H])C[C@@H](C)[C@@]6([H])O[C@@]5([H])C[C@@]4([H])O[C@@]3(C)CC=C[C@@]1([H])O2 \|w:74.82,c:48\|
密度	1.187g/cm3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.

Brevetoxin-3