PKR activators can be beneficial to treat disorders and conditions such as but not limited to PKD, thalassemia, hereditary elliptocytosis, anemia (e.g. , congenital anemias (e.g., enzymopathies), hemolytic anemia (e.g. hereditary and/or congenital hemolytic anemia, acquired hemolytic anemia, chronic hemolytic anemia caused by phosphoglycerate kinase deficiency, anemia of chronic diseases, non-spherocytic hemolytic anemia or hereditary spherocytosis)[1].