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Lorglumide sodium salt

Name: Lorglumide sodium salt
Brand: TargetMol
SKU: T11868
Price: 848 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.32%

货号 T11868Cas号 1021868-76-7

别名 氯戊米特钠盐, CR-1409 sodium salt

Lorglumide sodium salt (CR-1409 sodium salt) 是胆囊收缩素受体 (CCK) 的拮抗剂。

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Lorglumide sodium salt

一键复制产品信息

很棒

纯度: 99.32%

货号 T11868 别名 氯戊米特钠盐, CR-1409 sodium saltCas号 1021868-76-7

Lorglumide sodium salt (CR-1409 sodium salt) 是胆囊收缩素受体 (CCK) 的拮抗剂。

规格	价格	库存
1 mg	¥ 153	现货
5 mg	¥ 328	现货
10 mg	¥ 513	现货
25 mg	¥ 848	现货
50 mg	待询	现货
1 mL x 10 mM (in DMSO)	¥ 348	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.32%

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COA LCMS HNMR 产品操作手册

产品介绍

Lorglumide sodium salt AI Summary

Lorglumide sodium salt exhibits a multifaceted range of bioactivities, demonstrating potent inhibition in several biological processes including Lamin A splicing, ALDH1A1 inhibition, Influenza NS1 Protein function inhibition, Histone Lysine Methyltransferase G9a inhibition, Polymerase Iota inhibition, TGF-b inhibition, ATXN expression blocking, and Ebola Virus entry inhibition, with activities noted in the low nanomolar and micromolar ranges. Additionally, the compound inhibits sodium fluorescein uptake in OATP1B3- and OATP1B1-transfected CHO cells, with inhibition percentages of 32.85% and 16.54%, and Ki values of 2710.0 nM and 2010.0 nM respectively. Lorglumide sodium salt also demonstrates moderate affinity for the CCK-A receptor with an IC50 of 170.0 nM and exhibits antiproliferative activities against various cancer cell lines (MiaPaCa, AGS, PANC, and MAC13) with IC50 values ranging from 289.0 to 421.0 nM. Furthermore, it shows activity in inhibiting cell viability in SARS-CoV-2-infected Vero E6 cells at an MOI of 0.002 after 72 hours, with an inhibition index of 0.5123 relative to arbidol control. These findings indicate its potential for diverse therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Lorglumide sodium salt (CR-1409 sodium salt) is an antagonist of cholecystokinin receptors (CCK).
别名	氯戊米特钠盐, CR-1409 sodium salt

化学信息

分子量	481.39
分子式	C₂₂H₃₁Cl₂N₂NaO₄
CAS No.	1021868-76-7
Smiles	CCCCCN(C(C(NC(C1=CC(Cl)=C(Cl)C=C1)=O)CCC([O-])=O)=O)CCCCC.[Na+]
密度	no data available

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 90 mg/mL (186.96 mM), Sonication is recommended.

H2O: 100 mg/mL (207.73 mM), Sonication is recommended.

体内实验配方

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.86 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0773 mL	10.3866 mL	20.7732 mL	103.8659 mL
5 mM	0.4155 mL	2.0773 mL	4.1546 mL	20.7732 mL
10 mM	0.2077 mL	1.0387 mL	2.0773 mL	10.3866 mL
20 mM	0.1039 mL	0.5193 mL	1.0387 mL	5.1933 mL
50 mM	0.0415 mL	0.2077 mL	0.4155 mL	2.0773 mL
100 mM	0.0208 mL	0.1039 mL	0.2077 mL	1.0387 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。