规格

价格

库存

数量

25 mg

¥ 132

现货

50 mg

¥ 178

现货

1 mL x 10 mM (in DMSO)

¥ 272

现货

生物活性

产品描述	Toremifene citrate is a selective estrogen receptor modulator (SERM). It is an estrogen agonist for bone tissue and cholesterol metabolism but is antagonistic on the mammary and uterine tissue.
靶点活性	SERM:1±0.3 μM
体外活性	在DEN诱导的大鼠中,Toremifene在最高测试剂量下,提高肝细胞癌和肾上腺样瘤的发生率.
体内活性	在肿瘤细胞中,Toremifene（5-10 mM ）能够上调TRPM-2和TGF beta1的mRNA的水平。在人乳腺癌细胞中,Toremifene（7.5 mM ）能够诱导细胞凋亡或发生程序性死亡。在DMBA诱导的大鼠乳腺肿瘤中,Toremifene通过抑制有丝分裂活性和修改大量自发凋亡来影响细胞周期的。
激酶实验	cDNA encoding the human MT1 gene is introduced into CHO cells. Cells are harvested at confluence in Ca2+ and Mg2+ free Hanks' balanced salt solution containing 5 mM EDTA and collected by centrifugation. Cells are homogenized in ice-cold 50 mM Tris–HCl buffer, washed twice, pelleted, and stored at -30°C until the binding assays are conducted. Test compound and 40 pM 2-[ 125I]melatonin are mixed with the thawed homogenate in a total volume of 1 mL and incubated at 25°C for 150 min. The reaction is terminated by addition of 3 mL of icecold buffer followed by vacuum filtration on a Whatman GF/B. The filter is washed twice and radioactivity is counted by a g-counter[1].
别名	枸橼酸托瑞米芬, NSC 613680, NK 622, FC 1157a

化学信息

分子量	598.08
分子式	C₃₂H₃₆ClNO₈
CAS No.	89778-27-8
Smiles	C(=C(\c1ccccc1)/CCCl)(\c1ccc(cc1)OCCN(C)C)/c1ccccc1.C(CC(=O)O)(CC(=O)O)(C(=O)O)O
密度	1.045g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

H2O: <1 mg/mL

DMSO: 93 mg/mL (155.5 mM), Sonication is recommended.

Ethanol: <1 mg/mL

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (5.52 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

Toremifene citrate