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Anti-WNK1 Antibody (1O394)
还可以产品编号 TMAH-01252
别名 WNK 1, Serine/threonine-protein kinase WNK1, Protein kinase with no lysine 1, Protein kinase lysine-deficient 1, PRKWNK1, p65, Kinase deficient protein, KIAA0344, KDP, hWNK1, HSN2, Erythrocyte 65 kDa protein, EC 2.7.11.1
Anti-WNK1 Antibody (1O394) 是一种抗体，靶向 WNK1。Anti-WNK1 Antibody (1O394) 可用于 ELISA, IHC。
Anti-WNK1 Antibody (1O394)
Anti-WNK1 Antibody (1O394)
还可以产品编号 TMAH-01252 别名 WNK 1, Serine/threonine-protein kinase WNK1, Protein kinase with no lysine 1, Protein kinase lysine-deficient 1, PRKWNK1, p65, Kinase deficient protein, KIAA0344, KDP, hWNK1, HSN2, Erythrocyte 65 kDa protein, EC 2.7.11.1
Anti-WNK1 Antibody (1O394) 是一种抗体，靶向 WNK1。Anti-WNK1 Antibody (1O394) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,310 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-WNK1 Antibody (1O394) is an antibody targeting WNK1. Anti-WNK1 Antibody (1O394) can be used in ELISA, IHC. |
| 别名 | WNK 1, Serine/threonine-protein kinase WNK1, Protein kinase with no lysine 1, Protein kinase lysine-deficient 1, PRKWNK1, p65, Kinase deficient protein, KIAA0344, KDP, hWNK1, HSN2, Erythrocyte 65 kDa protein, EC 2.7.11.1 |
| Ig Type | Rabbit IgG |
| 克隆号 | 1O394 |
| 交叉反应 | Human |
| 验证活性 | 1. IHC image of TMAH-01252 diluted at 1:50 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.60% DAB. 2. IHC image of TMAH-01252 diluted at 1:50 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.60% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Cytoplasm. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition. Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human WNK1 |
| 抗原种属 | Human |
| 基因ID | 65125 |
| Uniprot ID | |
| 研究领域 | Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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