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Anti-ICOS ligand Antibody (1W488)
还可以产品编号 TMAY-01901
Anti-ICOS ligand Antibody (1W488) 是一种 Mouse 抗体，靶向 ICOS ligand。Anti-ICOS ligand Antibody (1W488) 可用于 FCM。
Anti-ICOS ligand Antibody (1W488)
Anti-ICOS ligand Antibody (1W488)
还可以产品编号 TMAY-01901
Anti-ICOS ligand Antibody (1W488) 是一种 Mouse 抗体，靶向 ICOS ligand。Anti-ICOS ligand Antibody (1W488) 可用于 FCM。
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产品介绍
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偶联与修饰
抗原信息
| 产品描述 | Anti-ICOS ligand Antibody (1W488) is a Mouse antibody targeting ICOS ligand. Anti-ICOS ligand Antibody (1W488) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1W488 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of Human ICOSLG(CD275) expression on RPMI8226 cells. Cells were stained with purified anti-Human ICOSLG(CD275), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM |
| 推荐剂量 | FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ICOS Ligand / B7-H2 (rh ICOS Ligand / B7-H2; TMPY-01672; NP_056074.1; Met1-Ser258). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Inducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. The present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production, and germinal center formation.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/FITC/PE |
| 可提供抗体种类 | 4 |
| 免疫原 | Recombinant Human ICOS Ligand / B7-H2 Protein (TMPY-01672) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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