Name: AMG-1694
Brand: TargetMol
SKU: T14212
Price: 910 CNY
Availability: InStock
Rating: 5 (10 reviews)

规格

价格

库存

数量

1 mg

¥ 910

现货

5 mg

¥ 2,170

现货

10 mg

¥ 2,980

现货

25 mg

¥ 4,410

现货

50 mg

¥ 5,960

现货

100 mg

¥ 8,050

现货

200 mg

¥ 10,800

现货

产品介绍

生物活性

产品描述	AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates GK translocation.
靶点活性	GK:0.02 μM(EC50), GK-GKRP:7 nM
体外活性	AMG-1694在GKRP存在下，高效地恢复了GK的酶活性，其EC50为0.020 μM。[1]

化学信息

分子量	533.63
分子式	C₂₃H₃₀F₃N₃O₄S₂
CAS No.	1361217-07-3
Smiles	C([C@@H]1N(CCN(S(=O)(=O)C2=CC=CS2)C1)C3=CC=C([C@@](C(F)(F)F)(C)O)C=C3)N4[C@@H](C)COCC4
密度	1.348 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 50 mg/mL (93.7 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.75 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

体内实验配液计算器