Name: Men 10376
Brand: TargetMol
SKU: T16038
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

500 μg

¥ 1,720

35日内发货

1 mg

¥ 2,970

35日内发货

5 mg

¥ 11,800

35日内发货

生物活性

产品描述	Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor.
靶点活性	NK2R (rat small intestine):(ki)4.4 μM
体外活性	Men 10376 is a selective tachykinin NK-2 receptor (Ki: 4.4 μM). Men 10376 displays no effect on NK-3 receptor (Ki, >10 μM). It also displays low selectivity for NK-1 and NK-3 receptors (Ki, >10 μM)[1]. Men 10376 shows pA2s of 5.66 and 8.08 for NK-1 (guinea-pig ileum) and NK-2 receptors (endothelium-deprived rabbit pulmonary artery). [2].
体内活性	Men 10376 (1 and 3 μmol/kg; in rats) antagonizes an enhance in bladder motility produced by the NK-2 receptor agonist [2].
别名	Neurokinin-2 receptor antagonist

化学信息

分子量	1081.22
分子式	C₅₇H₆₈N₁₂O₁₀
CAS No.	135306-85-3
Smiles	C([C@H](C(N[C@H](CC=1C=2C(NC1)=CC=CC2)C(N[C@@H](CCCCN)C(N)=O)=O)=O)NC([C@@H](NC([C@@H](CC=3C=4C(NC3)=CC=CC4)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CC(O)=O)N)=O)=O)=O)C(C)C)=O)C=6C=7C(NC6)=CC=CC7
密度	1.361 g/cm3 (Predicted)
Sequence	Asp-Tyr-{d-Trp}-Val-{d-Trp}-{d-Trp}-Lys-NH2
Sequence Short	DY-{d-Trp}-V-{d-Trp}{d-Trp}-K-NH2