购物车
  • 全部删除
  • TargetMol
    您的购物车当前为空

NUDIX hydrolase

Nudix hydrolases are a superfamily of hydrolytic enzymes capable of cleaving nucleoside diphosphates linked to x (any moiety), hence their name. The reaction yields nucleoside monophosphate (NMP) plus X-P. Substrates hydrolysed by nudix enzymes comprise a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity. Enzymes of the Nudix superfamily are found in all types of organisms, including eukaryotes, bacteria and archaea.

  • TH1760
    T678642567914-01-4
    TH1760 (MKB) 是有效的 NUDIX-type 15 (NUDT15) 抑制剂 (IC50= 25 nM)。TH1760 可以通过增强核酸中 6-thio-(d) GTP 的积累增加细胞对 6-硫代鸟嘌呤的敏感程度。TH1760 增强了硫基嘌呤的抗白血病作用。
    • ¥ 167
    现货
    规格
    数量
  • TH5427
    T39785L2253744-56-6
    TH5427 在 NUDT5 活性和 ADP-核糖代谢中有研究的价值。它阻断孕激素依赖性、PAR 衍生的核 ATP 合成以及随后的乳腺癌细胞染色质重塑、基因调控和增殖。NUDT5是乳腺癌细胞激素依赖性基因调控和增殖的变阻器。
    • ¥ 696
    现货
    规格
    数量
    TargetMol | Inhibitor Sale