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Rosoxacin

Name: Rosoxacin
Brand: TargetMol
SKU: T16789
Price: 413 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.1%

货号 T16789Cas号 40034-42-2

别名 罗索沙星, Acrosoxacin

Rosoxacin (Acrosoxacin) 是具有口服活性的喹诺酮类抗生素，具有广谱的抗菌活性，抑制革兰氏阴性菌，包括淋病奈瑟氏球菌(MIC90=0.03 mg/ml)。它在尿路感染中有应用的潜能。

为众多的药物研发团队赋能，

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Rosoxacin

一键复制产品信息

很棒

纯度: 99.1%

货号 T16789 别名 罗索沙星, AcrosoxacinCas号 40034-42-2

规格	价格	库存
1 mg	¥ 413	现货
5 mg	¥ 892	现货
10 mg	¥ 1,490	现货
25 mg	¥ 3,130	现货
50 mg	¥ 4,480	现货
100 mg	¥ 6,320	现货
200 mg	¥ 8,520	现货
1 mL x 10 mM (in DMSO)	¥ 856	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

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纯度: 99.1%

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资源下载:

COA LCMS HNMR 产品操作手册

产品介绍

生物活性

产品描述	Rosoxacin (Acrosoxacin) shows antibacterial activities against a broad spectrum of Gram-negative bacteria including Neisseria gonorrhoeae (MIC90 = 0.03mg/ml).
靶点活性	Neisseria gonorrhoeae:0.03 mg/ml (MIC90)
别名	罗索沙星, Acrosoxacin

化学信息

分子量	294.3
分子式	C₁₇H₁₄N₂O₃
CAS No.	40034-42-2
Smiles	CCn1cc(C(O)=O)c(=O)c2ccc(cc12)-c1ccncc1
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 20.83 mg/mL (70.78 mM), Sonication is recommended.

体内实验配方

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.8 mM), Sonication is recommended.

请按顺序添加溶剂，在添加下一种溶剂之前，尽可能使溶液澄清。如有必要，可通过加热、超声、涡旋处理进行溶解。工作液建议现配现用。以上配方仅供参考，体内配方并不是绝对的，请根据不同情况进行调整。

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3979 mL	16.9895 mL	33.9789 mL	169.8947 mL
5 mM	0.6796 mL	3.3979 mL	6.7958 mL	33.9789 mL
10 mM	0.3398 mL	1.6989 mL	3.3979 mL	16.9895 mL
20 mM	0.1699 mL	0.8495 mL	1.6989 mL	8.4947 mL
50 mM	0.0680 mL	0.3398 mL	0.6796 mL	3.3979 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20g，给药体积100 μL， TargetMol | Animal experiments

一共给药动物10只，您使用的配方为5% TargetMol | reagent

DMSO + 30%PEG300 + 5%Tween 80 + 60%Saline /PBS/ddH₂O，那么您的工作液浓度为2mg/mL。

母液配置方法: 2 mg 药物溶于 50 μLDMSO TargetMol | reagent

（母液浓度为 40 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法: 取 50μLDMSO TargetMol | reagent

母液，添加 300 μLPEG300 TargetMol | reagent

混匀澄清，再加 50μLTween80, 混匀澄清，再加 600μLSaline /PBS/ddH₂O TargetMol | reagent

混匀澄清

以上为“体内实验配液计算器”的使用方法举例，并不是具体某个化合物的推荐配制方式，请根据您的实验动物和给药方式选择适当的溶解方案。

方案所需的各类助溶剂如： DMSO ， PEG300 / PEG400 ， Tween 80 ， SBE-β-CD ，玉米油等，均可在TargetMol网站点击购买。

剂量转换

对于不同动物的给药剂量换算，您也可以参考更多

TargetMol AI Summary

Rosoxacin exhibits noteworthy bioactivity as both an antimicrobial and antiviral agent. In antimicrobial studies, it demonstrated potent antibacterial properties with Minimum Inhibitory Concentration (MIC) values against various bacterial strains, including Staphylococcus aureus (0.4-0.5 µg/mL), Escherichia coli (0.125-0.2 µg/mL), and moderate activity against Pseudomonas aeruginosa (6.3-16.0 µg/mL). It also showed activity against Klebsiella pneumoniae with a MIC of 0.4 µg/mL, suggesting broad-spectrum antibacterial potential. Additionally, Rosoxacin has antimalarial efficacy, showing lower IC50 values against the chloroquine-sensitive Plasmodium falciparum NF54-R strain (10.6 µg/mL). In terms of antiviral activity, Rosoxacin has been found to inhibit SARS-CoV-2's cytotoxicity in VERO-6 and Caco-2 cells, albeit with varying results, such as a relatively weak inhibition rate in some assays. It also demonstrated inhibition of the 3CL-Pro protease of SARS-CoV-2 with a 9.673% inhibition rate at 20 µM concentration. Furthermore, the compound has shown some activity against herpes simplex virus-2 (HSV-2) with a maximum tolerated level greater than 200.0 µg/mL. Lastly, Rosoxacin was tested for its ability to inhibit human HDAC6 in enzymatic assays, achieving an inhibition rate of 30.62% with a commercial peptide substrate, although results varied with different substrates. Overall, Rosoxacin holds promise across multiple bioactivity domains, including antimicrobial, antiviral, and antimalarial properties..

Note: Summary generated by AI, AI may be wrong some times, we do not provide any medical advice and only sell our product to accredited institution, Please cross-check with other sources, data source: chembl