MST1 Protein, Human, Recombinant (His)

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产品编号 TMPY-04398

Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.

MST1 Protein, Human, Recombinant (His)

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产品编号 TMPY-04398

规格	价格	库存
5 μg	¥ 582	3日内发货
10 μg	¥ 939	现货
20 μg	¥ 1,590	5日内发货
50 μg	¥ 3,670	5日内发货

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产品信息

生物活性	The specific activity was determined to be ＞150 nmol/min/mg using MBP as substrate.
产品描述	Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.
种属	Human
表达系统	Baculovirus Insect Cells
标签	N-His
蛋白编号	Q13043-1
别名	YSK3,TIIAC,serine/threonine kinase 4,MST1,KRS2
蛋白构建	A DNA sequence encoding the human STK4 isoform 1 (Q13043-1) (Glu 2-Phe 487) was expressed, with a polyhistidine tag at the N-terminus. Predicted N terminal: His
蛋白纯度	> 92 % as determined by SDS-PAGE.
分子量	58 kDa (predicted); 58 kDa (reducing conditions)
内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
蛋白性状	Solution
缓冲液	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
研究背景	Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.