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MST1 Protein, Human, Recombinant (His)

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货号 TMPY-04398

别名 YSK3, TIIAC, serine/threonine kinase 4, MST1, KRS2

Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.

MST1 Protein, Human, Recombinant (His)

MST1 Protein, Human, Recombinant (His)

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Rating icon 很棒
货号 TMPY-04398 别名 YSK3, TIIAC, serine/threonine kinase 4, MST1, KRS2

Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.

规格价格库存数量
5 μg
¥ 582
现货
10 μg
¥ 939
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20 μg
¥ 1,590
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50 μg
¥ 3,670
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选择批次:
纯度: > 92 % as determined by SDS-PAGE.
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资源下载:
COA重组蛋白用户指南

产品介绍

生物活性
产品描述
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.
生物活性
The specific activity was determined to be ＞150 nmol/min/mg using MBP as substrate.
研究背景
Dysregulation of MST1/STK4, a key kinase component of the Hippo-YAP pathway, is linked to the etiology of many cancers with poor prognosis. STK4/Hippo pathway may have important therapeutic implications for cancer. The tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated Hepatocellular carcinoma (HCC). STK4 has potential as a diagnostic biomarker and therapeutic target for inflammation-induced HCC.
种属
Human
表达系统
Baculovirus Insect Cells
标签N-His
蛋白编号Q13043-1
蛋白构建A DNA sequence encoding the human STK4 isoform 1 (Q13043-1) (Glu 2-Phe 487) was expressed, with a polyhistidine tag at the N-terminus. Predicted N terminal: His
蛋白纯度
> 92 % as determined by SDS-PAGE.
蛋白性状Solution
缓冲液Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol.
复溶方法A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
别名YSK3, TIIAC, serine/threonine kinase 4, MST1, KRS2
内毒素< 1.0 EU/μg of the protein as determined by the LAL method.
化学信息
分子量58 kDa (predicted); 58 kDa (reducing conditions)
颜色Transparent
物理性状Liquid
储存&溶解度
运输方式Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice.
存储It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

计算器

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剂量转换

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技术支持

请阅读 重组蛋白用户指南 了解更多具体信息.

关键词

YSK-3YSK 3MST-1MST 1KRS-2KRS 2
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