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Erasin是一种STAT3抑制剂(IC50=9.7 μM),抑制STAT3酪氨酸磷酸化的选择性高于STAT5和STAT1,在多种癌细胞系(如 MDA-MB-231、HCC-827)中诱导癌细胞凋亡,对Erlotinib耐药的癌细胞同样有效。

Erasin是一种STAT3抑制剂(IC50=9.7 μM),抑制STAT3酪氨酸磷酸化的选择性高于STAT5和STAT1,在多种癌细胞系(如 MDA-MB-231、HCC-827)中诱导癌细胞凋亡,对Erlotinib耐药的癌细胞同样有效。
| 规格 | 价格 | 库存 | 数量 | 
|---|---|---|---|
| 2 mg | ¥ 499  | In stock | 
Erasin 相关产品
| 产品描述 | Erasin is a STAT3 inhibitor (IC50 = 9.7 μM) with higher selectivity for inhibiting STAT3 tyrosine phosphorylation than STAT5 and STAT1. It induces apoptosis in various cancer cell lines (e.g., MDA-MB-231, HCC-827) and is effective against Erlotinib-resistant cancer cells.  | 
| 靶点活性 |  STAT3:9.7 μM, STAT1:24 μM  | 
| 体外活性 | 方法:  | 
| 分子量 | 349.38 | 
| 分子式 | C20H19N3O3 | 
| Smiles | CC(C)(C)C1=CC(C2=O)=C(C=C1)OC=C2/C=N/NC(C3=CC=CN=C3)=O | 
| 存储 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| 溶解度信息 | DMSO: 30 mg/mL (85.87 mM), Sonication is recommended.   | ||||||||||||||||||||||||||||||
溶液配制表  | |||||||||||||||||||||||||||||||
DMSO 
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