Name: Endothelin 1 (swine, human)
Brand: TargetMol
SKU: T19309
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

¥ 5,533

5日内发货

产品介绍

生物活性

产品描述	Endothelin 1 (swine, human) is a potent endogenous vasoconstrictor peptide released primarily by endothelial cells and acting through ETA and ETB receptors. Endothelin 1 (swine, human) mediates vascular smooth-muscle contraction, promotes fibrosis, stimulates reactive oxygen species production, and induces pro-inflammatory signaling, making it central to studies of vascular dysfunction, hypertension, and oxidative stress–associated pathology.
体外活性	It acts through two types of receptors: ETA and ETB.?Apart from a vasoconstrictive action, ET-1 causes fibrosis of the vascular cells and stimulates production of reactive oxygen species.?It is claimed that ET-1 induces proinflammatory mechanisms, increasing superoxide anion production and cytokine secretion.Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by endothelial cells.
别名	内皮缩血管肽 1 (猪,人)

化学信息

分子量	2491.9
分子式	C₁₀₉H₁₅₉N₂₅O₃₂S₅
CAS No.	117399-94-7
Smiles	C([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CN=CN1)NC(=O)[C@H]2NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H]([C@H](C)C)NC(=O)[C@]5(NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@](NC(=O)[C@H](CO)NC(=O)[C@@H](N)CSSC2)(CSSC5)[H])[H])=O)CC(C)C)=O)CC(O)=O)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)C(O)=O)C=6C=7C(NC6)=CC=CC7
密度	1.273 g/cm3 (Predicted)
颜色	White
物理性状	Solid
Sequence	Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)
Sequence Short	CSCSSLMDKECVYFCHLDIIW (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

储存&溶解度

存储

keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: ≥ 40 mg/mL, Sonication is recommended.

H2O: 50 mg/mL (20.07 mM), Sonication is recommended.

溶液配制表

H2O

	1mg	5mg	10mg	50mg
1 mM	0.4013 mL	2.0065 mL	4.0130 mL	20.0650 mL
5 mM	0.0803 mL	0.4013 mL	0.8026 mL	4.0130 mL
10 mM	0.0401 mL	0.2007 mL	0.4013 mL	2.0065 mL
20 mM	0.0201 mL	0.1003 mL	0.2007 mL	1.0033 mL

体内实验配液计算器