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顶部生物活性储存和溶解信息计算器

Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)

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Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)
产品编号 TMAC-03761
别名 sirtuin 1, SIRT1 (p-Ser47), SIRT1 (p-S47), SIR2L1, p-SIRT1 (Ser47), p-SIRT1 (S47)

Anti-Phospho-SIRT1 (S47) Antibody (5Z724) 是一种 Rabbit 抗体，靶向 Phospho-SIRT1 (S47)。Anti-Phospho-SIRT1 (S47) Antibody (5Z724) 可用于 WB,ICC,IHC。

Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)

Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)

Rating icon 还可以
Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724)
产品编号 TMAC-03761 别名 sirtuin 1, SIRT1 (p-Ser47), SIRT1 (p-S47), SIR2L1, p-SIRT1 (Ser47), p-SIRT1 (S47)

Anti-Phospho-SIRT1 (S47) Antibody (5Z724) 是一种 Rabbit 抗体，靶向 Phospho-SIRT1 (S47)。Anti-Phospho-SIRT1 (S47) Antibody (5Z724) 可用于 WB,ICC,IHC。

规格价格库存数量
50 μL
¥ 1,485
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100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724) 是一种 Rabbit 抗体，靶向 Phospho-SIRT1 (Ser47)。Anti-Phospho-SIRT1 (Ser47) Antibody (5Z724) 可用于 WB,ICC,IHC。
别名sirtuin 1, SIRT1 (p-Ser47), SIRT1 (p-S47), SIR2L1, p-SIRT1 (Ser47), p-SIRT1 (S47)
Ig Type
IgG
交叉反应
Human
验证活性
1. Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-SIRT1(phospho S47) antibody. Counter stained with hematoxylin.
2. ICC staining SIRT1(phospho S47) in A549 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
3. ICC staining SIRT1(phospho S47) in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
4. ICC staining SIRT1(phospho S47) in SW480 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
应用
WB
ICC
IHC
推荐剂量
WB: 1:1000; IHC: 1:50-200; ICC: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Hybridoma Monoclonal Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景The silent information regulator (SIR2) family of genes are highly-conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 is highly expressed in heart, brain and skeletal muscle, with low expression in lung and placenta. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lys 382.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
A synthesized phosphopeptide: human SIRT1 around the phosphorylation site of Ser47
抗原种属
human
Uniprot ID
Q96EB6
化学信息
分子量Theoretical: 82 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

SIRT1 (pSer47)SIRT1 (pS47)SIRT1 (phospho-Ser47)SIRT1 (phospho-S47)pSIRT1 (Ser47)pSIRT1 (S47)

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4个月前
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