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Anti-KRT19 Antibody (6A728)
还可以产品编号 TMAY-00118
Anti-KRT19 Antibody (6A728) 是一种 Mouse 抗体，靶向 KRT19。Anti-KRT19 Antibody (6A728) 可用于 IHC-P。
Anti-KRT19 Antibody (6A728)
Anti-KRT19 Antibody (6A728)
还可以产品编号 TMAY-00118
Anti-KRT19 Antibody (6A728) 是一种 Mouse 抗体，靶向 KRT19。Anti-KRT19 Antibody (6A728) 可用于 IHC-P。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,679 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-KRT19 Antibody (6A728) is a Mouse antibody targeting KRT19. Anti-KRT19 Antibody (6A728) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG3 |
| 克隆号 | 6A728 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human KRT19 in human thyroid cancer with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human KRT19 in human liver with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human KRT19 in human hepatoma with mouse monoclonal antibody (1:500, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:250-1:1000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human KRT19. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Cytokeratin 19 (KRT19) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 is overexpressed and may play a crucial role in tumorigenic transformation. The KRT19 gene encodes cytokeratin 19, an element of the cytoskeleton whose expression is frequently altered in renal cell carcinoma (RCC).KRT19 was identified as one of the key biomarkers for distinguishing cholangiocarcinoma (CCA) and hepatocellular carcinoma. Expression of KRT19 was specifically high in breast cancers and significantly correlated with their invasiveness. Moreover, knockdown of KRT19 led to increased proliferation, migration, invasion, drug resistance, and sphere formation in breast cancer cells via an upregulated NOTCH signaling pathway. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the center region of the Human KRT19 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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