Name: Manelimab
Brand: TargetMol
SKU: T77079
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

5 mg

待询

生物活性

产品描述	Manelimab is a humanized monoclonal antibody targeting Programmed death-ligand 1(PD-L1). By blocking the interaction between PD-L1 and its receptor PD-1, it can relieve the immunosuppression of T cells, thus enhancing the anti-tumor immune response. Manelimab is mainly used to explore the mechanism of tumor immunotherapy.
体外活性	Manelimab 高亲和力结合人 IL-10Ra，触发 STAT3 磷酸化并模拟 IL-10 信号传导。在纳摩尔 (nM) 浓度下，它能剂量依赖性地抑制 LPS 刺激引起的单核细胞促炎细胞因子（如 TNF-alpha 和 IL-6）的分泌 [1]。
别名	玛奈利单抗, BCD-135
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q9NZQ7
靶点	PD-L1

化学信息

CAS No.

2168561-26-8

储存&溶解度

存储	Store at -20°C Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

Manelimab