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Anti-Podoplanin Antibody (6Y710)
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产品编号 TMAH-00873
别名 TI1A, T1A-2, T1A2, T1A, podoplanin, PA2.26, OTS8, HT1A-1, GP40, Gp38, GP36, AGGRUS
Anti-Podoplanin Antibody (6Y710) 是一种抗体，靶向 Podoplanin。Anti-Podoplanin Antibody (6Y710) 可用于 ELISA。
Anti-Podoplanin Antibody (6Y710)
Anti-Podoplanin Antibody (6Y710)
还可以产品编号 TMAH-00873 别名 TI1A, T1A-2, T1A2, T1A, podoplanin, PA2.26, OTS8, HT1A-1, GP40, Gp38, GP36, AGGRUS
Anti-Podoplanin Antibody (6Y710) 是一种抗体，靶向 Podoplanin。Anti-Podoplanin Antibody (6Y710) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,315 | 5日内发货 | |
| 100 μL | ¥ 2,190 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-Podoplanin Antibody (6Y710) is an antibody targeting Podoplanin. Anti-Podoplanin Antibody (6Y710) can be used in ELISA. |
| 别名 | TI1A, T1A-2, T1A2, T1A, podoplanin, PA2.26, OTS8, HT1A-1, GP40, Gp38, GP36, AGGRUS |
| Ig Type | Rabbit IgG |
| 克隆号 | 6Y710 |
| 交叉反应 | Human |
| 应用 | |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | [Podoplanin]: Membrane; Single-pass type I membrane protein. Cell projection, lamellipodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Cell projection, microvillus membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Membrane raft. Apical cell membrane. Basolateral cell membrane. Cell projection, invadopodium.; [29kDa cytosolic podoplanin intracellular domain]: Cytoplasm, cytosol. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activation and/or aggregation. Interaction with CD9, on the contrary, attenuates platelet aggregation induced by PDPN. Through MSN or EZR interaction promotes epithelial-mesenchymal transition (EMT) leading to ERZ phosphorylation and triggering RHOA activation leading to cell migration increase and invasiveness. Interaction with CD44 promotes directional cell migration in epithelial and tumor cells. In lymph nodes (LNs), controls fibroblastic reticular cells (FRCs) adhesion to the extracellular matrix (ECM) and contraction of the actomyosin by maintaining ERM proteins (EZR; MSN and RDX) and MYL9 activation through association with unknown transmembrane proteins. Engagement of CLEC1B by PDPN promotes FRCs relaxation by blocking lateral membrane interactions leading to reduction of ERM proteins (EZR; MSN and RDX) and MYL9 activation. Through binding with LGALS8 may participate in connection of the lymphatic endothelium to the surrounding extracellular matrix. In keratinocytes, induces changes in cell morphology showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Controls invadopodia stability and maturation leading to efficient degradation of the extracellular matrix (ECM) in tumor cells through modulation of RHOC activity in order to activate ROCK1/ROCK2 and LIMK1/LIMK2 and inactivation of CFL1. Required for normal lung cell proliferation and alveolus formation at birth. Does not function as a water channel or as a regulator of aquaporin-type water channels. Does not have any effect on folic acid or amino acid transport. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human PDPN |
| 抗原种属 | Human |
| 基因ID | |
| Uniprot ID | |
| 研究领域 | Cardiovascular |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
计算器
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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