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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Dnmt1 Antibody (6Q563)

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货号 TMAB-05258

Anti-Dnmt1 Antibody (6Q563) 是一种 Rabbit 抗体，靶向 Dnmt1。Anti-Dnmt1 Antibody (6Q563) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-Dnmt1 Antibody (6Q563)

Anti-Dnmt1 Antibody (6Q563)

一键复制产品信息
Rating icon 还可以
货号 TMAB-05258

Anti-Dnmt1 Antibody (6Q563) 是一种 Rabbit 抗体，靶向 Dnmt1。Anti-Dnmt1 Antibody (6Q563) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 785
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-Dnmt1 Antibody (6Q563) is a Rabbit antibody targeting Dnmt1. Anti-Dnmt1 Antibody (6Q563) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
克隆号
6Q563
反应种属
Human,Mouse,Rat
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus.
组织特异性Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Methylation of DNA at cytosine residues in mammalian cells is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting and development. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.
抗原信息
免疫原
A synthesized peptide: human DNMT1
抗原种属
Human
基因名称
DNMT1
基因ID
1786
蛋白名称
DNA(cytosine-5)-methyltransferase 1
Uniprot ID
P26358
功能
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
化学信息
分子量Theoretical: 183 kDa. Actual: 183 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
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