ORL1 antagonist 1

Name: ORL1 antagonist 1
Brand: TargetMol
SKU: T12320
Price: 323 CNY
Availability: InStock
Rating: 5 (10 reviews)

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纯度: 98.92%

货号 T12320Cas号 1174985-59-1

ORL1 antagonist 1是阿片样受体1 (ORL1) 拮抗剂， IC50 值为 61 nM。

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ORL1 antagonist 1

一键复制产品信息

很棒

纯度: 98.92%

货号 T12320Cas号 1174985-59-1

ORL1 antagonist 1是阿片样受体1 (ORL1) 拮抗剂， IC50 值为 61 nM。

规格	价格	库存
1 mg	¥ 323	现货
5 mg	¥ 749	现货
10 mg	¥ 1,090	现货
25 mg	¥ 1,730	现货
50 mg	¥ 2,380	现货
100 mg	¥ 3,220	现货
200 mg	¥ 4,330	现货
1 mL x 10 mM (in DMSO)	¥ 742	现货

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COA HNMR LCMS 产品操作手册

产品介绍

ORL1 antagonist 1 AI Summary

ORL1 antagonist 1 shows significant bioactivity with an IC50 of 61.0 nM in the displacement assay of [125I]Tyr14-NC/OFQ from the human ORL1 receptor, indicating high activity in this pathway. It also exhibits an IC50 of 23000.0 nM in the assay of displacement of [35S]MK499 from human ERG expressed in HEK293 cells, reflecting a much lower activity in this context. Additionally, the compound has a LogD value of 1.3 in lipophilicity assessment at pH 7.4, suggesting a moderate partition coefficient..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	ORL1 antagonist 1 is an o antagonist of pioid receptor-like 1 (ORL1) (IC50 of 61 nM).
靶点活性	ORL1:61 nM

化学信息

分子量	367.88
分子式	C₂₀H₂₂ClN₅
CAS No.	1174985-59-1
Smiles	CC1=C(N(N=C1CNC2CCCC2)C3=C(Cl)C=CC=N3)C=4C=CC=NC4
密度	1.32 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

溶解度信息

DMSO: 55 mg/mL (149.51 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7183 mL	13.5914 mL	27.1828 mL	135.9139 mL
5 mM	0.5437 mL	2.7183 mL	5.4366 mL	27.1828 mL
10 mM	0.2718 mL	1.3591 mL	2.7183 mL	13.5914 mL
20 mM	0.1359 mL	0.6796 mL	1.3591 mL	6.7957 mL
50 mM	0.0544 mL	0.2718 mL	0.5437 mL	2.7183 mL
100 mM	0.0272 mL	0.1359 mL	0.2718 mL	1.3591 mL