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Anti-CD36 Antibody (2P125)

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Anti-CD36 Antibody (2P125)
产品编号 TMAH-00191
别名 SR-B3, SRB3, SCARB3, PAS-4, PAS IV, GPIV, GPIIIb, GP3B, FATCHDS7, FAT, CHDS7, CD36, BDPLT10

Anti-CD36 Antibody (2P125) 是一种抗体，靶向 CD36。Anti-CD36 Antibody (2P125) 可用于 ELISA, IHC。

Anti-CD36 Antibody (2P125)

Anti-CD36 Antibody (2P125)

Rating icon 还可以
Anti-CD36 Antibody (2P125)
产品编号 TMAH-00191 别名 SR-B3, SRB3, SCARB3, PAS-4, PAS IV, GPIV, GPIIIb, GP3B, FATCHDS7, FAT, CHDS7, CD36, BDPLT10

Anti-CD36 Antibody (2P125) 是一种抗体，靶向 CD36。Anti-CD36 Antibody (2P125) 可用于 ELISA, IHC。

规格价格库存数量
50 μL
¥ 1,305
5日内发货
100 μL
¥ 2,185
5日内发货
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产品介绍

生物活性
产品描述
Anti-CD36 Antibody (2P125) is an antibody targeting CD36. Anti-CD36 Antibody (2P125) can be used in ELISA, IHC.
别名SR-B3, SRB3, SCARB3, PAS-4, PAS IV, GPIV, GPIIIb, GP3B, FATCHDS7, FAT, CHDS7, CD36, BDPLT10
Ig Type
Rabbit IgG
克隆号
2P125
交叉反应
Human
验证活性
1. IHC image of TMAH-00191 diluted at 1:100 and staining in paraffin-embedded human spleen tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.25% DAB.
2. IHC image of TMAH-00191 diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.25% DAB.
应用
ELISA
IHC
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位Cell membrane; Multi-pass membrane protein. Membrane raft. Golgi apparatus. Apical cell membrane.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependency on coreceptor signaling is strongly ligand specific. Cellular responses to these ligands are involved in angiogenesis, inflammatory response, fatty acid metabolism, taste and dietary fat processing in the intestine. Binds long-chain fatty acids and facilitates their transport into cells, thus participating in muscle lipid utilization, adipose energy storage, and gut fat absorption. In the small intestine, plays a role in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, possibly through the activation of MAPK1/3 (ERK1/2) signaling pathway. Involved in oral fat perception and preferences. Detection into the tongue of long-chain fatty acids leads to a rapid and sustained rise in flux and protein content of pancreatobiliary secretions. In taste receptor cells, mediates the induction of an increase in intracellular calcium levels by long-chain fatty acids, leading to the activation of the gustatory neurons in the nucleus of the solitary tract. Important factor in both ventromedial hypothalamus neuronal sensing of long-chain fatty acid and the regulation of energy and glucose homeostasis. Receptor for thombospondins, THBS1 and THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4:TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, interacts with the heterodimer TLR4:TLR6, the complex is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion, through the priming and activation of the NLRP3 inflammasome. Selective and nonredundant sensor of microbial diacylated lipopeptide that signal via TLR2:TLR6 heterodimer, this cluster triggers signaling from the cell surface, leading to the NF-kappa-B-dependent production of TNF, via MYD88 signaling pathway and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. (Microbial infection) Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and the internalization of particles independently of TLR signaling.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
A synthetic peptide: Human CD36
抗原种属
Human
基因ID
948
Uniprot ID
P16671
研究领域
Cancer, Cardiovascular, Immunology, Metabolism, Microbiology, Stem cells
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

SRB-3SRB 3SCARB-3SCARB 3PAS4PAS 4FATCHDS-7FATCHDS 7CHDS-7CHDS 7CD-36CD 36BDPLT-10BDPLT 10

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