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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-RENT1+hUPF1 Polyclonal Antibody

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货号 TMAB-12192

Anti-RENT1+hUPF1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RENT1+hUPF1。Anti-RENT1+hUPF1 Polyclonal Antibody 可用于 WB。

Anti-RENT1+hUPF1 Polyclonal Antibody

Anti-RENT1+hUPF1 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-12192

Anti-RENT1+hUPF1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 RENT1+hUPF1。Anti-RENT1+hUPF1 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-RENT1+hUPF1 Polyclonal Antibody is a Rabbit antibody targeting RENT1+hUPF1. Anti-RENT1+hUPF1 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Dog,Cow,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Cytoplasm, P-body. Note=Hyperphosphorylated form is targeted to the P-body, while unphosphorylated protein is distributed throughout the cytoplasm.
组织特异性Ubiquitous.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (1–3). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.
抗原信息
免疫原
KLH conjugated synthetic peptide: human RENT1/hUPF1
抗原种属
Human
基因名称
UPF1
基因ID
5976
蛋白名称
Regulator of nonsense transcripts 1
功能
Plays a role in replication-dependent histone mRNA degradation at the end of phase S. Part of a post-splicing multiprotein complex. Involved in nonsense-mediated decay (NMD) as part of the SMG1C complex, a mRNA surveillance complex that recognizes and degrades mRNAs containing premature translation termination codons (PTCs). The complex probably acts by associating with ribosomes during tranlation termination on mRNPs. If an exon junction complex (EJC) is located 50-55 or more nucleotides downstream from the termination codon, RENT1 is phosphorylated by SMG1, triggering nonsense-mediated decay (NMD). Essential for embryonic viability.
化学信息
分子量Theoretical: 124 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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