CM-444 is an inhibitor of HDAC (IC50 ranging from 6 nM to 0.6 μM) and DNA methyltransferase (DNMT, IC50 ranging from 1.8 to 2.3 μM). This compound induces differentiation in acute myeloid leukemia cells, exhibits anti-leukemia activity, and enhances survival rates in mouse models.

DNMT3A:1.8 μM, HDAC2:51 nM, HDAC1:6.55 nM, HDAC9:90 nM, HDAC10:15 nM, HDAC8:83 nM, HDAC7:120 nM, HDAC4:62 nM, DNMT3B:2.3 μM, HDAC11:567.5 nM, HDAC3:18 nM, DNMT1:2.2 μM, HDAC6:531 nM, HDAC5:59 nM