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Anti-CDT1 Antibody (4Q313)

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Anti-CDT1 Antibody (4Q313)
产品编号 TMAC-00805
别名 RIS2, RIS 2, Retroviral integration site2, Retroviral integration site1, Retroviral integration site 2, Retroviral integration site 1, DUP, Double parked homolog, Double parked Drosophila homolog of, Double parked, DNA replication factor Cdt1, DNA replication factor, Chromatin licensing and DNA replication factor 1, CDT1_HUMAN, cdt1, CDT 1

Anti-CDT1 Antibody (4Q313) 是一种 Rabbit 抗体，靶向 CDT1。Anti-CDT1 Antibody (4Q313) 可用于 WB,IHC,IP。

Anti-CDT1 Antibody (4Q313)

Anti-CDT1 Antibody (4Q313)

Rating icon 还可以
Anti-CDT1 Antibody (4Q313)
产品编号 TMAC-00805 别名 RIS2, RIS 2, Retroviral integration site2, Retroviral integration site1, Retroviral integration site 2, Retroviral integration site 1, DUP, Double parked homolog, Double parked Drosophila homolog of, Double parked, DNA replication factor Cdt1, DNA replication factor, Chromatin licensing and DNA replication factor 1, CDT1_HUMAN, cdt1, CDT 1

Anti-CDT1 Antibody (4Q313) 是一种 Rabbit 抗体，靶向 CDT1。Anti-CDT1 Antibody (4Q313) 可用于 WB,IHC,IP。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-CDT1 Antibody (4Q313) is a Rabbit antibody targeting CDT1. Anti-CDT1 Antibody (4Q313) can be used in WB,IHC,IP.
别名RIS2, RIS 2, Retroviral integration site2, Retroviral integration site1, Retroviral integration site 2, Retroviral integration site 1, DUP, Double parked homolog, Double parked Drosophila homolog of, Double parked, DNA replication factor Cdt1, DNA replication factor, Chromatin licensing and DNA replication factor 1, CDT1_HUMAN, cdt1, CDT 1
Ig Type
IgG
交叉反应
Human
验证活性
1. Western blot analysis of CDT1 on Hela cell using anti-CDT1 antibody at 1/1,000 dilution.
2. Immunohistochemical analysis of paraffin-embedded human skin tissue using anti-CDT1 antibody. Counter stained with hematoxylin.
应用
WB
IHC
IP
推荐剂量
WB: 1:500-1000; IHC: 1:25-50
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Human Cdt1 is a nuclear localizing replication initiation factor that is expressed only during the G1 and S phases of the cell cycle. In conjunction with Cdc18, Cdt1 is required to load the MCM protein Cdc21 onto chromatin at the end of mitosis which is necessary to initiate DNA replication. After S-phase onset, Cdt1 protein levels decrease and are barely detectable in cells in early S-phase or G2. However, Cdt1 mRNA is expressed in S-phase-arrested cells, and its levels do not change dramatically during the cell cycle, suggesting that proteolytic degradation rather than transcriptional controls ensure proper accumulation of Cdt1. Cdt1 can associate with the DNA replication inhibitor geminin, which is present in the S and G2 phases of the cell cycle. Inhibition of DNA replication by geminin in cell-free DNA replication extracts can be reversed by the addition of excess Cdt1. Geminin may be responsible for preventing inappropriate origin firing by targeting Cdt1.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
Uniprot ID
Q9H211
化学信息
分子量Theoretical: 60 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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