Cinrebafusp alfa is a high-affinity CD137/HER2 bispecific antibody-like protein capable of specifically binding to recombinant human HER2 (Kd = 0.3 nM) and human monomeric CD137 (4-1BB, Kd = 5 nM). Cinrebafusp alfa is designed to target HER2-positive tumors by delivering activated 4-1BB to these sites, thereby mediating T-cell co-stimulatory signaling to exert an antitumor effect. It is indicated for the treatment of HER2-positive solid tumors.

MCF-7 cells (HER2 positive):7.4 nmol/L (EC50), CD137:5 nM (Kd), HER2:0.3 nM (Kd)

PRS 343

Human

Monoclonal, Bispecific

Unconjugated