Name: D574-0246
Brand: TargetMol
SKU: T213152
Rating: 4.5 (1 reviews)

规格

价格

库存

数量

10 mg

待询

10-14周

50 mg

待询

10-14周

生物活性

产品描述	D574-0246 is a dual-active inhibitor of OXCT1, targeting the enzyme's keto-dehydrogenase and succinyl-transferase activities. It reduces substrate-specific (LACTB K284) and global protein succinylation in HepG2 cells and lowers the ketolytic activity of OXCT1. The compound decreases the viability of HCC cells with an IC50 of 16.49 μM in PLC cells and 6.656 μM in HepG2 cells. In nude mice with HepG2 xenograft tumors overexpressing OXCT1, D574-0246 demonstrates anti-tumor effects. It is applicable for studies on hepatocellular carcinoma (HCC).
体外活性	D574-0246在4天内降低PLC细胞的存活率，IC 50为16.49 μM，并降低HepG2细胞的存活率，IC 50为6.656 μM。在1-10 μM范围内，D574-0246以剂量依赖方式显著减少HepG2细胞中底物特异性 (LACTB K284) 及全局蛋白的琥珀酰化。此外，D574-0246 (1-10 μM) 在HepG2细胞中显著降低OXCT1的酮解活性。
体内活性	D574-0246 (55 mg/kg，腹腔注射，每 3 天一次，共 8 次) 能有效抑制 OXCT1 过表达 HepG2 异种移植瘤的裸鼠的肿瘤生长'
别名	iOXCT1

化学信息

分子量	446.51
分子式	C₂₄H₂₆N₆O₃
CAS No.	1269110-12-4
Smiles	O=C(NC1=CC=C2OCOC2=C1)N3CCN(C4=NC(=NC(=C4)C)NC5=CC=C(C=C5)C)CC3

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. 实际储存温度请以COA为准

D574-0246