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顶部生物活性储存和溶解信息计算器

Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 2

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Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 2
产品编号 TMAC-02660
别名 p-MST1 (Thr183), p-MST1 (T183), MST1 (p-Thr183), MST1 (p-T183)

Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MST1 (Thr183)。Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 可用于 WB,IHC。

Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 2

Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 2

Rating icon 还可以
Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 2
产品编号 TMAC-02660 别名 p-MST1 (Thr183), p-MST1 (T183), MST1 (p-Thr183), MST1 (p-T183)

Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 是一种 Rabbit 抗体，靶向 Phospho-MST1 (Thr183)。Anti-Phospho-MST1 (Thr183) Polyclonal Antibody 可用于 WB,IHC。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Phospho-MST1 (Thr183) Polyclonal Antibody is a Rabbit antibody targeting Phospho-MST1 (Thr183). Anti-Phospho-MST1 (Thr183) Polyclonal Antibody can be used in WB,IHC.
别名p-MST1 (Thr183), p-MST1 (T183), MST1 (p-Thr183), MST1 (p-T183)
Ig Type
IgG
交叉反应
Human,Mouse
验证活性
1. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Mst1 (Phospho-Thr183) antibody TMAC-02660. The picture on the right is treated with the synthesized peptide.
2. Western blot analysis of extracts from 293 cells, treated with H2O2 (100uM, 15mins), using Mst1 (Phospho-Thr183) antibody TMAC-02660. The lane on the right is treated with the synthesized peptide.
应用
WB
IHC
推荐剂量
WB: 1:500-3000; IHC: 1:50-100
抗体种类
Polyclonal
宿主来源Rabbit
构建方式Polyclonal Antibody
纯化方式Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
性状Liquid
缓冲液Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
研究背景Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.
偶联与修饰
偶联
Unconjugated
其他可选修饰符
Phospho
抗原信息
免疫原
Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1
抗原种属
human
Uniprot ID
Q13043
化学信息
分子量Actual: 60 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

pMST1 (Thr183)pMST1 (T183)MST1 (pThr183)MST1 (pT183)MST1 (phospho-Thr183)MST1 (phospho-T183)

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