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Anti-PRMT6 Antibody (3W571)
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产品编号 TMAY-01844
别名 protein arginine methyltransferase 6, HRMT1L6
Anti-PRMT6 Antibody (3W571) 是一种 Mouse 抗体，靶向 PRMT6。Anti-PRMT6 Antibody (3W571) 可用于 WB,ELISA。
Anti-PRMT6 Antibody (3W571)
Anti-PRMT6 Antibody (3W571)
还可以产品编号 TMAY-01844 别名 protein arginine methyltransferase 6, HRMT1L6
Anti-PRMT6 Antibody (3W571) 是一种 Mouse 抗体，靶向 PRMT6。Anti-PRMT6 Antibody (3W571) 可用于 WB,ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,694 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-PRMT6 Antibody (3W571) is a Mouse antibody targeting PRMT6. Anti-PRMT6 Antibody (3W571) can be used in WB,ELISA. |
| 别名 | protein arginine methyltransferase 6, HRMT1L6 |
| Ig Type | Mouse IgG2b |
| 克隆号 | 3W571 |
| 交叉反应 | Human |
| 验证活性 | Anti-PRMT6 mouse monoclonal antibody at 1:500 dilution. -Lane A: 293T Whole Cell Lysate. -Lane B: A431 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG H&L (Dylight800) at 1/15000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:42 kDa. -Observed band size:55 kDa |
| 应用 | |
| 推荐剂量 | WB: 1:500-1:1000; ELISA: 1:5000-1:10000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PRMT6 (rh PRMT6; TMPY-01383; NP_060607.2; Met 1-Asp 375). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H3R2), and this negatively regulates the lysine methylation of H3K4 resulting in gene repression. PRMT6 plays a key role in coupling process by functioning as a transcriptional coactivator that can regulate alternative splicing. PRMT6 coactivates the progesterone, glucocorticoid and oestrogen receptors in luciferase reporter assays in a hormone-dependent manner. Small interfering RNA (siRNA) oligonucleotide duplex knockdown of PRMT6 disrupts oestrogen-stimulated transcription of endogenous GREB1 and progesterone receptor in MCF-7 breast cancer cells. Neutralizing the activity of PRMT6 could inhibit tumor progression and may be of cancer therapeutic significance. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Human PRMT6 protein (TMPY-01383) |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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