store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cyclo(L-Pro-L-Val) 是从辣椒溶杆菌AZ2和白斑分枝杆菌果实中提取出的 2,5-二酮哌嗪,具有抗炎活性,对植物病原微生物 (如 R. fascians LMG 3605) 具有毒性活性,能抑制革兰氏阳性植物病原菌。Cyclo(L-Pro-L-Val) 以浓度依赖性方式显著抑制了IKKα、IKKβ、IκBα和NF-κB 的磷酸化以及iNOS 和COX-2的活化,是治疗炎症相关疾病的潜在治疗剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 257 | 现货 | ||
10 mg | ¥ 413 | 现货 | ||
25 mg | ¥ 663 | 现货 | ||
50 mg | ¥ 970 | 现货 | ||
100 mg | ¥ 1,430 | 现货 | ||
500 mg | ¥ 3,580 | 现货 |
产品描述 | Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microorganisms (e.g., R. fascians LMG 3605) and inhibits Gram-positive plant pathogens.Cyclo(L-Pro-L-Val) significantly inhibited IKKα phosphorylation and IκBα and NF-κB activation as well as iNOS and COX-2 activation in a concentration Cyclo(L-Pro-L-Val) significantly inhibited the phosphorylation of IKKα, IKKβ, IκBα, and NF-κB, as well as the activation of iNOS and COX-2 in a concentration-dependent manner, and is a potential therapeutic agent for the treatment of inflammation-related diseases. |
分子量 | 196.25 |
分子式 | C10H16N2O2 |
CAS No. | 2854-40-2 |
store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (458.6 mM), Sonication is recommended.
CDCl3: 112.5 mg/mL (573.2 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / CDCl3 | 1 mM | 5.0955 mL | 25.4777 mL | 50.9554 mL | 127.3885 mL |
5 mM | 1.0191 mL | 5.0955 mL | 10.1911 mL | 25.4777 mL | |
10 mM | 0.5096 mL | 2.5478 mL | 5.0955 mL | 12.7389 mL | |
20 mM | 0.2548 mL | 1.2739 mL | 2.5478 mL | 6.3694 mL | |
50 mM | 0.1019 mL | 0.5096 mL | 1.0191 mL | 2.5478 mL | |
100 mM | 0.051 mL | 0.2548 mL | 0.5096 mL | 1.2739 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Cyclo(L-Pro-L-Val) 2854-40-2 Immunology/Inflammation Microbiology/Virology Neuroscience NF-Κb COX NF-κB NOS IκB/IKK Antibacterial Inhibitor inhibitor inhibit